MyBioSource.com's Lamin A antibody is a Rabbit Polyclonal antibody. This antibody has been shown to work in applications such as: Immunohistochemistry, and Western Blot. The Lamin A antibody was generated using cdcd1, cddc, Dhe, FPLD, idc, Lamin A, Lamin A/C, Lamin C, ldp1, lmn1, LMNA, and LMNL1 as the antigen and it reacts with Human, Mouse, Rat, and Xenopus/Amphibian.
Description
Rabbit polyclonal Lamin A antibody
Lamins are nuclear membrane structural components that are important in maintaining normal cell functions such as cell cycle control, DNA replication and chromatin organization. Lamin A is specifically cleaved by caspase-6 and therefore serves as a marker for caspase-6 activation. During apoptosis the 70 kDa lamin A is cleaved to a large and small fragment. The cleavage of lamins results in nuclear disregulation and cell death